Tetrahedron letters

Zinc-catalyzed Williamson ether synthesis in the absence of base

S Paul, M Gupta

文献索引：Paul, Satya; Gupta, Monika Tetrahedron Letters, 2004 , vol. 45, # 48 p. 8825 - 8829

被引用次数: 53

摘要

Zinc powder was found to be a highly efficient catalyst for the synthesis of aromatic ethers using microwave heating in the presence of N, N-dimethylformamide as well as under stirring in an oil-bath using tetrahydrofuran as solvent without any inorganic base. This method can be used for selective mono-, di-or tri-O-alkylations.

~84%

~84%

~74%

~94%

~78%

~79%

~74%

~67%

~80%

~81%

~79%

~79%

~76%

~73%

~64%

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[Bharate, Sandip B.; Khan, Shabana I.; Yunus, Nafees A.M.; Chauthe, Siddheshwar K.; Jacob, Melissa R.; Tekwani, Babu L.; Khan, Ikhlas A.; Singh, Inder Pal Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 87 - 96]