Novel diarylsulfonylurea derivatives as potent antimitotic agents

S Kim, JH Park, SY Koo, JI Kim, MH Kim, JE Kim…

Index: Kim, Semi; Park, Ji Hyun; Koo, Sun-Young; Kim, Jung In; Kim, Min-Hyeung; Kim, Ji Eun; Jo, Kiwon; Geun Choi, Hwan; Lee, Sung Bae; Jung, Sang-Hun Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 6075 - 6078

Full Text: HTML

Citation Number: 23

Abstract

A novel series of diarylsulfonylurea derivatives were synthesized and evaluated for interaction with tubulin and for cytotoxicity against human cancer cell lines. These derivatives demonstrated good inhibitory activity against tubulin polymerization, which was well correlated with promising antiproliferative activity as well as G2/M phase cell cycle arrest. Furthermore, several compounds were also efficacious against multidrug-resistant ...