Novel diarylsulfonylurea derivatives as potent antimitotic agents

S Kim, JH Park, SY Koo, JI Kim, MH Kim, JE Kim…

文献索引：Kim, Semi; Park, Ji Hyun; Koo, Sun-Young; Kim, Jung In; Kim, Min-Hyeung; Kim, Ji Eun; Jo, Kiwon; Geun Choi, Hwan; Lee, Sung Bae; Jung, Sang-Hun Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 6075 - 6078

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被引用次数: 23

摘要

A novel series of diarylsulfonylurea derivatives were synthesized and evaluated for interaction with tubulin and for cytotoxicity against human cancer cell lines. These derivatives demonstrated good inhibitory activity against tubulin polymerization, which was well correlated with promising antiproliferative activity as well as G2/M phase cell cycle arrest. Furthermore, several compounds were also efficacious against multidrug-resistant ...