Anticonvulsant activity of some 4-aminobenzamides

CR Clark, MJM Wells, RT Sansom…

Index: Clark; Wells; Sansom; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 779 - 782

Full Text: HTML

Citation Number: 73

Abstract

A series of 4-aminobenzamides of some simple primary and secondary amines were prepared and evaluated for anticonvulsant effects. The compounds were tested in mice against seizures induced by electroshock and p8ntylenetetrazole (metrazole) and in the rotorod assay for neurologic deficit. For those N-alkyl amides tested, 4-amino-N- amylbenzamide (6) was the most potent against maximal electroshock seizures (MES): ...

 Related Synthetic Route
N-ethyl-4-nitro-benzamide Structure

50445-50-6

N-ethyl-4-nitro...

~80%

4-Amino-N-ethylbenzamide Structure

89399-17-7

4-Amino-N-ethyl...

N-cyclohexyl-4-nitro-benzamide Structure

7506-46-9

N-cyclohexyl-4-...

~81%

4-Amino-N-cyclohexylbenzamide Structure

17675-42-2

4-Amino-N-cyclo...

4-Nitrobenzoyl chloride Structure

122-04-3

4-Nitrobenzoyl ...

Amylamine Structure

110-58-7

Amylamine

~67%

4-nitro-N-pentyl-benzamide Structure

89399-20-2

4-nitro-N-penty...

4-Nitrobenzoyl chloride Structure

122-04-3

4-Nitrobenzoyl ...

N-Methylbenzylamine Structure

103-67-3

N-Methylbenzylamine

~69%

N-benzyl-N-methyl-4-nitrobenzamide Structure

89399-23-5

N-benzyl-N-meth...

4-nitro-N,N-dipropyl-benzamide Structure

79868-22-7

4-nitro-N,N-dip...

~79%

4-amino-N,N-dipropylbenzamide Structure

79868-19-2

4-amino-N,N-dip...

Dipropylamine Structure

142-84-7

Dipropylamine

~%

4-amino-N,N-dipropylbenzamide Structure

79868-19-2

4-amino-N,N-dip...

4-Nitrobenzoyl chloride Structure

122-04-3

4-Nitrobenzoyl ...

~%

4-amino-N,N-dipropylbenzamide Structure

79868-19-2

4-amino-N,N-dip...

4-Nitrobenzoyl chloride Structure

122-04-3

4-Nitrobenzoyl ...

~%

1-[5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]PIPERIDINE-4-OL Structure

85592-75-2

1-[5-(TRIFLUORO...

1-Phenylethanamine Structure

618-36-0

1-Phenylethanamine

~%

1-[5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]PIPERIDINE-4-OL Structure

85592-75-2

1-[5-(TRIFLUORO...

4-nitro-N-pentyl-benzamide Structure

89399-20-2

4-nitro-N-penty...

~78%

4-amino-N-pentylbenzamide Structure

85592-76-3

4-amino-N-penty...

4-Nitrobenzoyl chloride Structure

122-04-3

4-Nitrobenzoyl ...

~%

4-amino-N-pentylbenzamide Structure

85592-76-3

4-amino-N-penty...

Amylamine Structure

110-58-7

Amylamine

~%

4-amino-N-pentylbenzamide Structure

85592-76-3

4-amino-N-penty...

4-Nitrobenzoyl chloride Structure

122-04-3

4-Nitrobenzoyl ...

Dipropylamine Structure

142-84-7

Dipropylamine

~67%

4-nitro-N,N-dipropyl-benzamide Structure

79868-22-7

4-nitro-N,N-dip...

N-butyl-4-nitro-benzamide Structure

51207-98-8

N-butyl-4-nitro...

~78%

4-Amino-N-butylbenzamide Structure

51207-84-2

4-Amino-N-butyl...

4-Nitrobenzoyl chloride Structure

122-04-3

4-Nitrobenzoyl ...

~%

4-Amino-N-butylbenzamide Structure

51207-84-2

4-Amino-N-butyl...

N-n-Hexyl-4-nitrobenzamide Structure

89399-21-3

N-n-Hexyl-4-nit...

~82%

4-amino-N-hexylbenzamide Structure

85592-77-4

4-amino-N-hexyl...

Hexylamine Structure

111-26-2

Hexylamine

~%

4-amino-N-hexylbenzamide Structure

85592-77-4

4-amino-N-hexyl...

4-Nitrobenzoyl chloride Structure

122-04-3

4-Nitrobenzoyl ...

~%

4-amino-N-hexylbenzamide Structure

85592-77-4

4-amino-N-hexyl...

N-benzyl-N-methyl-4-nitrobenzamide Structure

89399-23-5

N-benzyl-N-meth...

~81%

4-amino-N-benzyl-N-methylbenzamide Structure

85592-78-5

4-amino-N-benzy...

4-Nitrobenzoyl chloride Structure

122-04-3

4-Nitrobenzoyl ...

~%

4-amino-N-benzyl-N-methylbenzamide Structure

85592-78-5

4-amino-N-benzy...

N-Methylbenzylamine Structure

103-67-3

N-Methylbenzylamine

~%

4-amino-N-benzyl-N-methylbenzamide Structure

85592-78-5

4-amino-N-benzy...

4-nitro-N-(2-phenylpropyl)benzamide Structure

89399-22-4

4-nitro-N-(2-ph...

~82%

4-amino-N-(2-phenylpropyl)benzamide Structure

89399-18-8

4-amino-N-(2-ph...

2-phenylpropylamine Structure

582-22-9

2-phenylpropylamine

~%

4-amino-N-(2-phenylpropyl)benzamide Structure

89399-18-8

4-amino-N-(2-ph...

4-Nitrobenzoyl chloride Structure

122-04-3

4-Nitrobenzoyl ...

~%

4-amino-N-(2-phenylpropyl)benzamide Structure

89399-18-8

4-amino-N-(2-ph...

N-benzhydryl-4-nitrobenzamide Structure

88229-34-9

N-benzhydryl-4-...

~77%

4-amino-N-benzhydrylbenzamide Structure

89399-19-9

4-amino-N-benzh...

4-Nitrobenzoyl chloride Structure

122-04-3

4-Nitrobenzoyl ...

~%

4-amino-N-benzhydrylbenzamide Structure

89399-19-9

4-amino-N-benzh...

diphenylmethylamine Structure

91-00-9

diphenylmethylamine

~%

4-amino-N-benzhydrylbenzamide Structure

89399-19-9

4-amino-N-benzh...

Propylamine Structure

107-10-8

Propylamine

4-Nitrobenzoyl chloride Structure

122-04-3

4-Nitrobenzoyl ...

~70%

Benzamide,4-nitro-N-propyl- Structure

2585-24-2

Benzamide,4-nit...

2-phenylpropylamine Structure

582-22-9

2-phenylpropylamine

4-Nitrobenzoyl chloride Structure

122-04-3

4-Nitrobenzoyl ...

~72%

4-nitro-N-(2-phenylpropyl)benzamide Structure

89399-22-4

4-nitro-N-(2-ph...

4-Nitrobenzoyl chloride Structure

122-04-3

4-Nitrobenzoyl ...

~%

4-Aminobenzamide Structure

2835-68-9

4-Aminobenzamide


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