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Anticonvulsant activity of some 4-aminobenzamides

CR Clark, MJM Wells, RT Sansom…

文献索引:Clark; Wells; Sansom; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 779 - 782

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被引用次数: 73

摘要

A series of 4-aminobenzamides of some simple primary and secondary amines were prepared and evaluated for anticonvulsant effects. The compounds were tested in mice against seizures induced by electroshock and p8ntylenetetrazole (metrazole) and in the rotorod assay for neurologic deficit. For those N-alkyl amides tested, 4-amino-N- amylbenzamide (6) was the most potent against maximal electroshock seizures (MES): ...

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