The Journal of organic chemistry

Chloroperoxidase as enantioselective epoxidation catalyst: an efficient synthesis of (R)-(-)-mevalonolactone

FJ Lakner, LP Hager

Index: Lakner, Frederick J.; Hager, Lowell P. Journal of Organic Chemistry, 1996 , vol. 61, # 11 p. 3923 - 3925

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Citation Number: 116

Abstract

As an important intermediate in biosynthetic pathways leading to sterols, terpenes, corotenoids, and other pentanoid compounds, 1 (R)-(-)-mevalonic acid or especially its lactone form (4) has been a synthetic target of considerable interest. A number of chemical methodologies have been described, the most popular of which involves asymmetric induction provided by Sharpless epoxidation of a suitable allylic alcohol. 2 Chiral pool ...