Aryloxyacetic esters structurally related to α-Asarone as potential antifungal agents

…, MA Martínez, G Chamorro, F Díaz, J Tamariz

Index: Jimenez, Fabiola; Cruz, Maria Del Carmen; Zuniga, Clara; Martinez, Maria A.; Chamorro, German; Diaz, Francisco; Tamariz, Joaquin Medicinal Chemistry Research, 2010 , vol. 19, # 1 p. 33 - 57

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Citation Number: 2

Abstract

Abstract A series of aryloxyacetic ester analogues 8–13 was synthesized based on the potential pharmacophores of the antifungal agents α-Asarone (1) and 2–5. Their antifungal activity was tested in vitro for their growth inhibitory activities against pathogenic fungi. The in vitro antifungal evaluation of these alkyl and aryl esters shows that derivatives 10 displayed the highest antifungal and fungicidal activities against Cryptococcus ...