Novel radical alkylation of carboxylic imides

S Kim, CJ Lim, C Song, W Chung

Index: Kim, Sunggak; Lim, Chae Jo; Song, Changsik; Chung, Won-Jin Journal of the American Chemical Society, 2002 , vol. 124, # 48 p. 14306 - 14307

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Citation Number: 21

Abstract

Although alkylation is one of the most important and fundamental organic reactions, radical- mediated alkylations of carboxylic acid derivatives have not been well studied. The first successful radical alkylation of carboxylic imides is achieved by the addition of an alkyl radical to a ketene O, N-acetal and the subsequent cleavage of NO bond. It is noteworthy that alkyl halides activated with an electron-withdrawing group undergo alkylations under ...