European journal of medicinal chemistry

Design, synthesis and anticonvulsant evaluation of N-(benzo [d] thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3 (4H)-carbothioamide derivatives: a hybrid …

S Malik, RS Bahare, SA Khan

Index: Malik, Sachin; Bahare, Radhe Shyam; Khan, Suroor Ahmad European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 1 - 13

Full Text: HTML

Citation Number: 28

Abstract

Abstract Novel N-(benzo [d] thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3 (4H)- carbothioamide derivatives were synthesized and evaluation of their anticonvulsant effects was done using various models of experimental epilepsy. Initial anticonvulsant activities of the compounds were investigated using intraperitoneal (ip) maximal electroshock shock (MES), subcutaneous pentylenetetrazole (scPTZ) seizure models in mice. The quantitative ...