Design, synthesis and anticonvulsant evaluation of N-(benzo [d] thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3 (4H)-carbothioamide derivatives: a hybrid …
S Malik, RS Bahare, SA Khan
文献索引：Malik, Sachin; Bahare, Radhe Shyam; Khan, Suroor Ahmad European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 1 - 13
Abstract Novel N-(benzo [d] thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3 (4H)- carbothioamide derivatives were synthesized and evaluation of their anticonvulsant effects was done using various models of experimental epilepsy. Initial anticonvulsant activities of the compounds were investigated using intraperitoneal (ip) maximal electroshock shock (MES), subcutaneous pentylenetetrazole (scPTZ) seizure models in mice. The quantitative ...
