Index: Vartak, Ashish P.; Sonar, Vijayakumar; Crooks, Peter A. Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 10 p. 431 - 434
Abstract The synthesis of the d 4-forms of rac-and R-lofexidine was accomplished. Two methods are described; one method is a two-step synthesis of rac-d 4-lofexidine from 2- chloropropionitrile, the second method is a three-step preparation of Rd 4-lofexidine in absolute enantiomeric purity from S-methyl lactate. The commercial availability of R-methyl lactate makes this latter enantioselective synthesis applicable also to the synthesis of Sd 4 ...
