Rac??and R??(+)??[4, 4′, 5, 5′??2H4]??2??(1′??[2′′, 6′′??dichlorophenoxy]??ethyl)?螃?2??imidazoline (lofexidine)

AP Vartak, V Sonar, PA Crooks

文献索引：Vartak, Ashish P.; Sonar, Vijayakumar; Crooks, Peter A. Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 10 p. 431 - 434

全文：HTML全文

被引用次数: 0

摘要

Abstract The synthesis of the d 4-forms of rac-and R-lofexidine was accomplished. Two methods are described; one method is a two-step synthesis of rac-d 4-lofexidine from 2- chloropropionitrile, the second method is a three-step preparation of Rd 4-lofexidine in absolute enantiomeric purity from S-methyl lactate. The commercial availability of R-methyl lactate makes this latter enantioselective synthesis applicable also to the synthesis of Sd 4 ...