Tetrahedron letters

A new one-step synthesis of pyridines under microwave-assisted conditions

MC Bagley, R Lunn, X Xiong

Index: Bagley, Mark C; Lunn, Rebecca; Xiong, Xin Tetrahedron Letters, 2002 , vol. 43, # 46 p. 8331 - 8334

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Citation Number: 65

Abstract

Tri-or tetrasubstituted pyridines are prepared by microwave irradiation of ethyl β- aminocrotonate and various alkynones in a single synthetic step and with total control of regiochemistry. This new one-pot Bohlmann–Rahtz procedure conducted at 170° C in a self- tunable microwave synthesiser gives superior yields to similar experiments conducted using conductive-heating techniques in a sealed tube and can be carried out in the presence of ...