Tetrahedron letters

A new one-step synthesis of pyridines under microwave-assisted conditions

MC Bagley, R Lunn, X Xiong

文献索引：Bagley, Mark C; Lunn, Rebecca; Xiong, Xin Tetrahedron Letters, 2002 , vol. 43, # 46 p. 8331 - 8334

全文：HTML全文

被引用次数: 65

摘要

Tri-or tetrasubstituted pyridines are prepared by microwave irradiation of ethyl β- aminocrotonate and various alkynones in a single synthetic step and with total control of regiochemistry. This new one-pot Bohlmann–Rahtz procedure conducted at 170° C in a self- tunable microwave synthesiser gives superior yields to similar experiments conducted using conductive-heating techniques in a sealed tube and can be carried out in the presence of ...