The Journal of Organic Chemistry

Mild, selective, general method of ketone synthesis from acid chlorides and organotin compounds catalyzed by palladium

D Milstein, JK Stille

Index: Milstein,D.; Stille,J.K. Journal of Organic Chemistry, 1979 , vol. 44, p. 1613 - 1618

Full Text: HTML

Citation Number: 171

Abstract

Benzylchlorobis (triphenylphosphine) palladium (II) catalyzes the reaction of acid chlorides with tetraorganotin compounds t. 0 give ketones in quantitative yields. The reaction is general with respect to both reactants, and a wide variety of substituent groups on the acid chloride, including an aldehyde function, is tolerated, thus making this reaction one of the most general methods for ketone synthesis. The reaction is accelerated by oxygen, ...