The Journal of Organic Chemistry

Mild, selective, general method of ketone synthesis from acid chlorides and organotin compounds catalyzed by palladium

D Milstein, JK Stille

文献索引：Milstein,D.; Stille,J.K. Journal of Organic Chemistry, 1979 , vol. 44, p. 1613 - 1618

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被引用次数: 171

摘要

Benzylchlorobis (triphenylphosphine) palladium (II) catalyzes the reaction of acid chlorides with tetraorganotin compounds t. 0 give ketones in quantitative yields. The reaction is general with respect to both reactants, and a wide variety of substituent groups on the acid chloride, including an aldehyde function, is tolerated, thus making this reaction one of the most general methods for ketone synthesis. The reaction is accelerated by oxygen, ...