Tetrahedron letters

Bromine-magnesium-exchange as a general tool for the preparation of polyfunctional aryl and heteroaryl magnesium-reagents

M Abarbri, F Dehmel, P Knochel

Index: Abarbri, Mohamed; Dehmel, Florian; Knochel, Paul Tetrahedron Letters, 1999 , vol. 40, # 42 p. 7449 - 7453

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Citation Number: 130

Abstract

The scope of the Br Mg-exchange reaction for the preparation of polyfunctional aryl and heteroaryl magnesium reagents has been studied. Various functional groups (ester, cyano, bromide) were tolerated in the exchange reaction allowing the preparation of polyfunctional Mg-reagents. Several dibromo-or tribromoheterocycles undergo a chemoselective mono- Br Mg exchange leading to highly functionalized heterocycles.