Synthesis of 2-thiophenecarboxylic and 2, 5-thiophenedicarboxylic acid esters via the reaction of thiophenes with the CCl4-ROH reagent in the presence of vanadium, …

RI Khusnutdinov, NA Shchadneva, AR Baiguzina…

Index: Khusnutdinov; Shchadneva; Baiguzina; Mukminov; Mayakova; Smirnov; Dzhemilev Petroleum Chemistry, 2008 , vol. 48, # 6 p. 471 - 478

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Citation Number: 4

Abstract

Abstract 2-Thiophenecarboxylic and 2, 5-thiohenedicarboxylic acid esters were synthesized via the reaction of thiophene with the CCl 4-ROH-catalyst system, with a total yield of 44– 85%. A possible reaction scheme includes the successive steps of alkylation of thiophene with carbon tetrachloride, leading to 2-trichloromethylthiophene, and alcoholysis of the product giving the corresponding 2-thiophenecarboxylate. The best catalysts for this ...