Tetrahedron letters

Bromine-magnesium-exchange as a general tool for the preparation of polyfunctional aryl and heteroaryl magnesium-reagents

M Abarbri, F Dehmel, P Knochel

文献索引：Abarbri, Mohamed; Dehmel, Florian; Knochel, Paul Tetrahedron Letters, 1999 , vol. 40, # 42 p. 7449 - 7453

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被引用次数: 130

摘要

The scope of the Br Mg-exchange reaction for the preparation of polyfunctional aryl and heteroaryl magnesium reagents has been studied. Various functional groups (ester, cyano, bromide) were tolerated in the exchange reaction allowing the preparation of polyfunctional Mg-reagents. Several dibromo-or tribromoheterocycles undergo a chemoselective mono- Br Mg exchange leading to highly functionalized heterocycles.