Synthesis and in vitro antifungal evaluation of 2-(2, 4-difluorophenyl)-1-[(1 H-indol-3-ylmethyl) methylamino]-3-(1 H-1, 2, 4-triazol-1-yl) propan-2-ols

R Guillon, C Logé, F Pagniez…

Index: Journal of Enzyme Inhibition and Medicinal Chemistry, , vol. 26, # 2 p. 261 - 269

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Citation Number: 11

Abstract

... Journal of Enzyme Inhibition and Medicinal Chemistry. ... and accumulation of toxic intermediate sterols, causing increased membrane permeability and inhibition of fungal ... acid residue in Candida albicans sterol 14alpha-demethylase associated with the enzyme activity and ...