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Synthesis and in vitro antifungal evaluation of 2-(2, 4-difluorophenyl)-1-[(1 H-indol-3-ylmethyl) methylamino]-3-(1 H-1, 2, 4-triazol-1-yl) propan-2-ols

R Guillon, C Logé, F Pagniez…

文献索引:Journal of Enzyme Inhibition and Medicinal Chemistry, , vol. 26, # 2 p. 261 - 269

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被引用次数: 11

摘要

... Journal of Enzyme Inhibition and Medicinal Chemistry. ... and accumulation of toxic intermediate sterols, causing increased membrane permeability and inhibition of fungal ... acid residue in Candida albicans sterol 14alpha-demethylase associated with the enzyme activity and ...