Specific bradycardic agents. 1. Chemistry, pharmacology, and structure-activity relationships of substituted benzazepinones, a new class of compounds exerting …

M Reiffen, W Eberlein, P Mueller, M Psiorz…

Index: Reiffen; Eberlein; Muller; Psiorz; Noll; Heider; Lillie; Kobinger; Luger Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1496 - 1504

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Citation Number: 71

Abstract

Structural modification of the calcium-antagonist verapamil (1) by replacement of the lipophilic a-isopropylacetonitrile moiety by various heterocyclic ring systems has led to a new class of cardiovascular compounds which are characterized by a specific bradycardic activity. These agents reduce heart rate without binding to classical calcium channels or P- adrenoceptors, interacting instead specifically with structures at the sino atrial node. ...