Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3, 9-Difluoro-12, 13-dihydro-13-[6- …

BN Balasubramanian, DR St. Laurent…

Index: Journal of Medicinal Chemistry, , vol. 47, # 7 p. 1609 - 1612

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Citation Number: 28

Abstract

... Journal of Medicinal Chemistry. ... The indolocarbazole nucleus and its corresponding thio and oxo analogues were efficiently assembled via the chemistry described in Schemes 1 and 2. Stepwise addition of an appropriately substituted (eg, 19−26, 31−33, Table 1) indole ...

Synthesis of new 4??quinolone??type compounds in the benzo [...

[Fevrier; Dupas; Bourguignon; Queguiner Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 1085 - 1088]

C 17, 20-Lyase inhibitors I. Structure-based de novo design ...

[Matsunaga, Nobuyuki; Kaku, Tomohiro; Itoh, Fumio; Tanaka, Toshimasa; Hara, Takahito; Miki, Hiroshi; Iwasaki, Masahiko; Aono, Tetsuya; Yamaoka, Masuo; Kusaka, Masami; Tasaka, Akihiro Bioorganic and medicinal chemistry, 2004 , vol. 12, # 9 p. 2251 - 2273]

C 17, 20-Lyase inhibitors I. Structure-based de novo design ...

[Bioorganic and medicinal chemistry, , vol. 12, # 9 p. 2251 - 2273]