Design, synthesis and pharmacophoric model building of novel substituted nicotinic acid hydrazones with potential antiproliferative activity

HA Abdel-Aziz, T Aboul-Fadl, ARM Al-Obaid…

Index: Abdel-Aziz, Hatem A.; Aboul-Fadl, Tarek; Al-Obaid, Abdul-Rahman M.; Ghazzali, Mohamed; Al-Dhfyan, Abdullah; Contini, Alessandro Archives of Pharmacal Research, 2012 , vol. 35, # 9 p. 1543 - 1552

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Citation Number: 14

Abstract

Abstract Novel 6-aryl-2-methylnicotinic acid hydrazides 4a-c and their corresponding hydrazones 5a-c and 6a-i were synthesized. X-ray single crystal diffraction of 6h confirmed the chemical structure of hydrazones 6a-i. Antiproliferative activity of the synthetic compounds was investigated against K562 leukemia cell lines. Variable cell growth inhibitory activities were obtained with IC 50 range from 24.99 to 66.78 μM where the ...

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