One-step synthesis of pyridines and dihydropyridines in a continuous flow microwave reactor

…, RL Jenkins, MC Lubinu, C Mason

Index: Bagley, Mark C.; Fusillo, Vincenzo; Jenkins, Robert L.; Lubinu, M. Caterina; Mason, Christopher Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1957 - 1968

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Citation Number: 13

Abstract

Abstract The Bohlmann–Rahtz pyridine synthesis and the Hantzsch dihydropyridine synthesis can be carried out in a microwave flow reactor or using a conductive heating flow platform for the continuous processing of material. In the Bohlmann–Rahtz reaction, the use of a Brønsted acid catalyst allows Michael addition and cyclodehydration to be carried out in a single step without isolation of intermediates to give the corresponding trisubstituted ...