Highly stereoselective double (R)-phenylglycinol-induced cyclocondensation reactions of symmetric aryl bis (oxoacids)

…, C Arróniz, E Molins, C Escolano, J Bosch

Index: Amat, Mercedes; Arroniz, Carlos; Molins, Elies; Escolano, Carmen; Bosch, Joan Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2175 - 2184

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Citation Number: 4

Abstract

The double cyclocondensation of symmetric pyridyl bis (oxoacids) 2b and 3b with (R)- phenylglycinol stereoselectively gave access to bis-phenylglycinol-derived oxazolopyrrolidine 9 and oxazolopiperidone 10, respectively. Application of the stereocontrolled cyclocondensation reaction to phenyl bis-γ-oxoacid 4b provided 11, which was converted to the corresponding enantiopure di (pyrrolidinyl) benzene 22. The ...