e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
The Journal of Organic Chemistry
The Stereoselective Synthesis of 2-Alkyl. gamma.-Keto Acid and Heterocyclic Ketomethylene Peptide Isostere Core Units Using Chiral Alkylation by 2-Triflyloxy Esters
RV Hoffman, HO Kim
Index: Hoffman, Robert V.; Kim, Hwa-Ok Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5107 - 5113
A simple and general protocol for the enantioselective preparation of y-keto acids and heterocyclic y-keto acids which have an alkyl group at C-2 is reported. The alkyl group is introduced by chiral alkylation using a scalemic 2-triflyloxy ester. The alkylation takes place
