Journal of Heterocyclic Chemistry

Ring closure reactions with nitriles. II. Formation of pyrrolo [1, 2??a] quinazolines and thiazolo [3, 2??a] quinazolines

SC Bell, PHL Wei

Index: Bell,S.C.; Wei,P.H.L. Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 185 - 190

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Citation Number: 5

Abstract

Abstract 2-Quinazolinepropionic acids have been obtained from the reactions of potassium cyanide with o-carboxy-or o-acyl-3-chloropropionanilides. Some of these compounds have been cyclized to pyrrolo [1, 2-a] quinazolines. The reaction of an o-carbethoxy-2- chloroacetanilide with potassium thiocyanate formed a 2-quinazolinylthioacetic acid, which was cyclized to a thiazolo-[3, 2-a] quinazoline. A mechanism is presented for the formation ...