Tetrahedron letters

Silver nitrate-promoted ring enlargement of 1-tribromomethyl-1, 2-dihydro-and 1-tribromomethyl-1, 2, 3, 4-tetrahydro-isoquinoline derivatives: application to the …

M Pauvert, S Collet, A Guingant

Index: Pauvert, Mickael; Collet, Sylvain; Guingant, Andre Tetrahedron Letters, 2003 , vol. 44, # 22 p. 4203 - 4206

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Citation Number: 25

Abstract

The one step AgNO3-mediated ring enlargement of 1-tribromomethyl-1, 2-dihydro-and 1- tribromomethyl-1, 2, 3, 4-tetrahydro-isoquinoline derivatives into 1, 2-dihydro-and 1, 2, 3, 4- tetrahydro-benzo [d] azepin-2-ones, respectively, is reported. This reaction offers a convenient entry to potentially active substances such as the anti-anginal zatebradine.