Inhibitors of glycolic acid oxidase. 4-Substituted-2, 4-dioxobutanoic acid derivatives

HWR Williams, E Eichler, WC Randall…

Index: Williams, H. W. R.; Eichler, E.; Randall, W. C.; Rooney, C. S.; Cragoe, E. J.; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 8 p. 1196 - 1200

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Citation Number: 26

Abstract

Recently we describedl a series of 4-substituted 3-hydroxy-lH-pyrrole-2, 5-dione derivatives which were shown to be potent inhibitors of the enzyme glycolic acid oxidase (glycolate: Oz oxidoreductase, EC 1.1. 3.1)(GAO). This enzyme, which catalyzes the oxidation of glycolate to glyoxylate along with the conversion of the latter to oxalate, is considered to play an important role in oxalate production in plants and animak2 Earlier studies by Schuman ...