Benzylpiperazine derivatives. VI. Design and syntheses of vinylogs of 1-benzyl-4-diphenylmethylpiperazine derivatives and their cerebral vasodilating activities.

…, T KANAZAWA, K ITO, G TSUKAMOTO

Index: Ohtaka; Kanazawa; Ito; Tsukamoto Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 10 p. 4124 - 4129

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Abstract

As a lead development based on the previous quantitative structure-activity relationship (QSAR) results on cerebral vasodilating activities of 1-benzyl-4-diphenylmethylpiperazines, 1-cinnamyl-4-diphenylmethylpiperazines having electron-donating groups on the cinnamyl