Discovery of potential anti-inflammatory drugs: diaryl-1, 2, 4-triazoles bearing N-hydroxyurea moiety as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase

B Jiang, X Huang, H Yao, J Jiang, X Wu…

Index: Organic and Biomolecular Chemistry, , vol. 12, # 13 p. 2114 - 2127

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Citation Number: 17

Abstract

... 2. Results and discussion. 2.1. Chemistry. ... (v) 12, K 2 CO 3 , acetone ... 15, 0.167 ± 0.191. 2.6. Analgesic activity evaluation. Both chemical (acetic acid-induced writhing response) and thermal method (hot-plate assay) in mice were employed to investigate the analgesic activity of 15e ...