Synlett

Solid-phase assisted N-1 functionalization of azamacrocycles

M Oliver, MR Jorgensen, AD Miller

Index: Oliver, Morag; Jorgensen, Michael R.; Miller, Andrew D. Synlett, 2004 , # 3 p. 453 - 456

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Citation Number: 10

Abstract

Abstract A simple solid-phase assisted strategy for the N-1 functionalization of azamacrocycles is described. Compounds such as cyclen, cyclam and piperazine can be selectively modified by temporary attachment to solid-phase resins providing an efficient and clean method to prepare biomedically interesting moieteies.