Practical Asymmetric Hydrogenation-Based Synthesis of a Class-Selective Histone Deacetylase Inhibitor

J Chen, T Chen, Q Hu, K Püntener…

Index: Chintareddy, Venkat Reddy; Ellern, Arkady; Verkade, John G. Journal of Organic Chemistry, 2010 , vol. 75, # 21 p. 7166 - 7174

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Citation Number: 4

Abstract

... Select a Journal or Book ... For its synthesis the use of various bases (eg, KOtBu or NaH,(5) DBU, or Verkade's bicyclic triaminophosphine(6)) as well as ... Conditions: 5–10 g scale; molar equivalents relative to 4; sarcosine and paraformaldehyde were added in 2–4 portions for ...