Efficient Iron??Catalyzed Direct β??Alkylation of Secondary Alcohols with Primary Alcohols

…, DL Meng, HY Chen, ZH Zong, TT Feng…

Index: Yang, Jian; Liu, Xin; Meng, Da-Li; Chen, Hong-Yan; Zong, Zhi-Hui; Feng, Ting-Ting; Sun, Kai Advanced Synthesis and Catalysis, 2012 , vol. 354, # 2-3 p. 328 - 334

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Citation Number: 23

Abstract

Abstract The efficient iron-catalyzed direct β-alkylation of secondary alcohols with primary alcohols is described. In the presence of the commercially available iron catalyst ( ferrocenecarboxaldehyde, 1b) and a catalytic amount of base, the reactions give β-alkylated higher alcohols in high yields in the absence of any sacrificial agents (hydrogen acceptors or hydrogen donors) and nitrogen or phosphorus ligands. For the first time, iron is ...