Tetrahedron

Toward the enantioselective total synthesis of lyngbyatoxin A: on the stereocontrolled introduction of the quaternary stereogenic centre

JE Tønder, D Tanner

Index: Tonder, Janne E.; Tanner, David Tetrahedron, 2003 , vol. 59, # 35 p. 6937 - 6945

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Citation Number: 14

Abstract

This paper deals with an approach to the enantioselective total synthesis of Lyngbyatoxin A, with focus on the stereocontrolled introduction of the quaternary stereogenic centre. The key step in the synthesis involves an enantiospecific Lewis-acid mediated rearrangement of chiral vinyl epoxides carrying a 7-substituted indole moiety.