Tetrahedron

Toward the enantioselective total synthesis of lyngbyatoxin A: on the stereocontrolled introduction of the quaternary stereogenic centre

JE Tønder, D Tanner

文献索引：Tonder, Janne E.; Tanner, David Tetrahedron, 2003 , vol. 59, # 35 p. 6937 - 6945

全文：HTML全文

被引用次数: 14

摘要

This paper deals with an approach to the enantioselective total synthesis of Lyngbyatoxin A, with focus on the stereocontrolled introduction of the quaternary stereogenic centre. The key step in the synthesis involves an enantiospecific Lewis-acid mediated rearrangement of chiral vinyl epoxides carrying a 7-substituted indole moiety.