Acta Chem. Scand

Synthesis of DL-Statine and DL-4-Amino-3-hydroxy-4-phenylbutanoic acids via the isoxazoline route

K Hallig, KBG Torssell, RG Hazell

Index: Halling, Karen; Torssell, Kurt B. G.; Hazell, Rita G. Acta Chemica Scandinavica, 1991 , vol. 45, # 7 p. 736 - 741

Full Text: HTML

Citation Number: 15

Abstract

1, 3-Dipolar cycloaddition of chloronitrile oxide to N-allyltrichloroacétamides and subsequent reductive cleavage of the 3-methoxy-substituted isoxazolines gives methyl 3- hydroxy-4-trichloroacetamido esters which by acidic hydrolysis give the corresponding