Synthesis of benzo??halogenated 4??hydroxy??2 (1H)??quinolones

…, AS Karem, W Stadlbauer

Index: Kappe, Thomas; Karem, Abdel S.; Stadlbauer, Wolfgang Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 857 - 862

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Citation Number: 27

Abstract

Abstract Malondianilides 3 derived from dichloro substituted anilines 2 undergo cyclization to afford 4-hydroxy-2 (1H)-quinolones 4 in very good yields using methane sulfonic acid- phosphorus pentoxide as catalyst. 3, 4-Dichloro anilines 5 can be shown to yield two isomers, 7 and 8, whereas 3-substituted anilines 9 afford merely 7-substituted 4-hydroxy-2 (1H)-quinolones 11.