Abstract The major metabolite of sulpiride, N-[(1-ethyl-2-pyrrolidinyl) methyl]-5-sulfamoyl-2- anisamide (I), in the monkey is N-[(1-ethyl-5-oxo-2-pyrrolidinyl) methyl]-5-sulfamoyl-2- anisamide (II). It is also a metabolite in other laboratory animal species and possibly at very low levels in humans. Treatment of the urine from a monkey dosed orally with 14 CI by dry column chromatography and high-pressure liquid chromatography (HPLC) produced the ...
