Isolation, identification, and synthesis of the major sulpiride metabolite in primates

…, DG Westmoreland, MJ Williamson

文献索引：Brennan; Imondi; Westmoreland; Williamson Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 11 p. 1199 - 1203

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被引用次数: 5

摘要

Abstract The major metabolite of sulpiride, N-[(1-ethyl-2-pyrrolidinyl) methyl]-5-sulfamoyl-2- anisamide (I), in the monkey is N-[(1-ethyl-5-oxo-2-pyrrolidinyl) methyl]-5-sulfamoyl-2- anisamide (II). It is also a metabolite in other laboratory animal species and possibly at very low levels in humans. Treatment of the urine from a monkey dosed orally with 14 CI by dry column chromatography and high-pressure liquid chromatography (HPLC) produced the ...