Phytochemistry

Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica

…, H Søhoel, SR Denmeade, JT Isaacs, SB Christensen

Index: Liu, Huizhen; Jensen, Kent Gunnertoft; Tran, Linh My; Chen, Ming; Zhai, Lin; Olsen, Carl Erik; Sohoel, Helmer; Denmeade, Samuel R.; Isaacs, John T.; Brogger Christensen Phytochemistry, 2006 , vol. 67, # 24 p. 2651 - 2658

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Citation Number: 26

Abstract

Four phenylpropanoids and a thapsigargin analogue have been isolated from the fruits of Thapsia garganica. A spectroscopic method for elucidating the relative stereochemistry at the two pairs of stereogenic centers in the phenylpropanoids has been developed. The phenylpropanoids were found to be potent cytotoxins.