Synthesis of novel 2-alkyl-4-substituted-amino-pyrazolo [3, 4-d] pyrimidines as new leads for anti-bacterial and anti-cancer activity

M Devarakonda, R Doonaboina, S Vanga…

Index: Devarakonda, Murty; Doonaboina, Raghava; Vanga, Sreedher; Vemu, Jahnavi; Boni, Sathoshini; Mailavaram, Raghu Prasad Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1090 - 1101

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Citation Number: 7

Abstract

Abstract Treatment of 6-alkyl-1-phenyl-4-chloro-(1 H)-pyrazolo [3, 4-d] pyrimidines, with different amines afforded a series of compounds whose identity and purity were confirmed by spectral and analytical means. The compounds were tested for antibacterial activity against four organisms viz. Staphylococcus aureus (Gram positive), S. epidermidis (Gram positive), Bacillus subtilis (Gram positive), Escherichia coli (Gram negative) using ...

 Related Synthetic Route
5-amino-1-phenylpyrazole-4-carboxamide Structure

50427-77-5

5-amino-1-pheny...

~97%

6-methyl-1-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Structure

91974-63-9

6-methyl-1-phen...

5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile Structure

5334-43-0

5-Amino-1-pheny...

~%

6-methyl-1-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Structure

91974-63-9

6-methyl-1-phen...

4-Chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine Structure

5334-48-5

4-Chloro-1-phen...

isopropylamine Structure

75-31-0

isopropylamine

~69%

1H-Pyrazolo[3,4-d]pyrimidin-4-amine,N-(1-methylethyl)-1-phenyl- Structure

5334-52-1

1H-Pyrazolo[3,4...

5-amino-1-phenylpyrazole-4-carboxamide Structure

50427-77-5

5-amino-1-pheny...

~%

1H-Pyrazolo[3,4-d]pyrimidin-4-amine,N-(1-methylethyl)-1-phenyl- Structure

5334-52-1

1H-Pyrazolo[3,4...

4H-Pyrazolo[3,4-d]pyrimidin-4-one,1,5-dihydro-1-phenyl- Structure

21314-17-0

4H-Pyrazolo[3,4...

~%

1H-Pyrazolo[3,4-d]pyrimidin-4-amine,N-(1-methylethyl)-1-phenyl- Structure

5334-52-1

1H-Pyrazolo[3,4...

5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile Structure

5334-43-0

5-Amino-1-pheny...

~%

1H-Pyrazolo[3,4-d]pyrimidin-4-amine,N-(1-methylethyl)-1-phenyl- Structure

5334-52-1

1H-Pyrazolo[3,4...

5-amino-1-phenylpyrazole-4-carboxamide Structure

50427-77-5

5-amino-1-pheny...

~89%

1H-Pyrazolo[3,4-d]pyrimidin-4-ol, 6-ethyl-1-phenyl- Structure

5394-42-3

1H-Pyrazolo[3,4...

5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile Structure

5334-43-0

5-Amino-1-pheny...

~%

1H-Pyrazolo[3,4-d]pyrimidin-4-ol, 6-ethyl-1-phenyl- Structure

5394-42-3

1H-Pyrazolo[3,4...

5-amino-1-phenylpyrazole-4-carboxamide Structure

50427-77-5

5-amino-1-pheny...

~%

4-Chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine Structure

5334-48-5

4-Chloro-1-phen...

4-Chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine Structure

5334-48-5

4-Chloro-1-phen...

n-butylamine Structure

109-73-9

n-butylamine

~62%

N-butyl-9-phenyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-1,3,5,7-tetraen-5-amine Structure

68380-52-9

N-butyl-9-pheny...

5-amino-1-phenylpyrazole-4-carboxamide Structure

50427-77-5

5-amino-1-pheny...

~%

N-butyl-9-phenyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-1,3,5,7-tetraen-5-amine Structure

68380-52-9

N-butyl-9-pheny...

5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile Structure

5334-43-0

5-Amino-1-pheny...

~%

N-butyl-9-phenyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-1,3,5,7-tetraen-5-amine Structure

68380-52-9

N-butyl-9-pheny...

Furfurylamine Structure

617-89-0

Furfurylamine

4-Chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine Structure

5334-48-5

4-Chloro-1-phen...

~55%

N-(2-furylmethyl)-9-phenyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-1,3,5,7-tetraen-5-amine Structure

5326-74-9

N-(2-furylmethy...

5-amino-1-phenylpyrazole-4-carboxamide Structure

50427-77-5

5-amino-1-pheny...

~%

N-(2-furylmethyl)-9-phenyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-1,3,5,7-tetraen-5-amine Structure

5326-74-9

N-(2-furylmethy...

4H-Pyrazolo[3,4-d]pyrimidin-4-one,1,5-dihydro-1-phenyl- Structure

21314-17-0

4H-Pyrazolo[3,4...

~%

N-(2-furylmethyl)-9-phenyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-1,3,5,7-tetraen-5-amine Structure

5326-74-9

N-(2-furylmethy...

5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile Structure

5334-43-0

5-Amino-1-pheny...

~%

N-(2-furylmethyl)-9-phenyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-1,3,5,7-tetraen-5-amine Structure

5326-74-9

N-(2-furylmethy...

4-chloro-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine Structure

23121-14-4

4-chloro-6-meth...

Benzylamine Structure

100-46-9

Benzylamine

~56%

1H-Pyrazolo[3,4-d]pyrimidin-4-amine,6-methyl-1-phenyl-N-(phenylmethyl)- Structure

5401-50-3

1H-Pyrazolo[3,4...

5-amino-1-phenylpyrazole-4-carboxamide Structure

50427-77-5

5-amino-1-pheny...

~%

1H-Pyrazolo[3,4-d]pyrimidin-4-amine,6-methyl-1-phenyl-N-(phenylmethyl)- Structure

5401-50-3

1H-Pyrazolo[3,4...

6-methyl-1-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Structure

91974-63-9

6-methyl-1-phen...

~%

1H-Pyrazolo[3,4-d]pyrimidin-4-amine,6-methyl-1-phenyl-N-(phenylmethyl)- Structure

5401-50-3

1H-Pyrazolo[3,4...

5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile Structure

5334-43-0

5-Amino-1-pheny...

~%

1H-Pyrazolo[3,4-d]pyrimidin-4-amine,6-methyl-1-phenyl-N-(phenylmethyl)- Structure

5401-50-3

1H-Pyrazolo[3,4...

4-chloro-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine Structure

23121-14-4

4-chloro-6-meth...

Ethylamine Structure

75-04-7

Ethylamine

~56%

N-ethyl-3-methyl-9-phenyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-1,3,5,7-tetraen-5-amine Structure

5346-47-4

N-ethyl-3-methy...

5-amino-1-phenylpyrazole-4-carboxamide Structure

50427-77-5

5-amino-1-pheny...

~%

N-ethyl-3-methyl-9-phenyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-1,3,5,7-tetraen-5-amine Structure

5346-47-4

N-ethyl-3-methy...

6-methyl-1-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Structure

91974-63-9

6-methyl-1-phen...

~%

N-ethyl-3-methyl-9-phenyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-1,3,5,7-tetraen-5-amine Structure

5346-47-4

N-ethyl-3-methy...

5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile Structure

5334-43-0

5-Amino-1-pheny...

~%

N-ethyl-3-methyl-9-phenyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-1,3,5,7-tetraen-5-amine Structure

5346-47-4

N-ethyl-3-methy...


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