Journal of the American Chemical Society

Hantzsch's pyridine synthesis

AP Phillips

Index: Phillips Journal of the American Chemical Society, 1949 , vol. 71, p. 4003,4004

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Citation Number: 96

Abstract

The Hantzsch pyridine synthesis' has been run using cinchoninaldehyde, 2 m- nitrobenzaldehyde, p-dimethylamino-and p-diethylaminobenzaldehydes as the aromatic aldehydic reactants, and with a variety of alkyl acetoacetates as the ester components. The first products obtained by this synthesis were all of the normal dihydropyridine type, and manifested weak analgesic and curare-like activities in laboratory animals.