The Hantzsch pyridine synthesis' has been run using cinchoninaldehyde, 2 m- nitrobenzaldehyde, p-dimethylamino-and p-diethylaminobenzaldehydes as the aromatic aldehydic reactants, and with a variety of alkyl acetoacetates as the ester components. The first products obtained by this synthesis were all of the normal dihydropyridine type, and manifested weak analgesic and curare-like activities in laboratory animals.
![[3-[3,5-bis(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl]phenyl]-trimethylazanium,iodide结构式](https://image.chemsrc.com/caspic/211/66941-33-1.png)
