A practical method for activation of commercial lithium hydride: reductive silylation of carbonyl compounds with lithium hydride and chlorotrimethylsilane

T Ohkuma, S Hashiguchi, R Noyori

Index: Ohkuma, Takeshi; Hashiguchi, Shohei; Noyori, Ryoji Journal of Organic Chemistry, 1994 , vol. 59, # 1 p. 217 - 221

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Citation Number: 35

Abstract

Commercially available lithium hydride, an essentially inert metal hydride, can be activated as a hydride source by an equimolar amount of chlorotrimethylsilane and a catalytic amount of a Zn salt or Zn powder. Aromatic and aliphatic ketones, as well as nonenolizable aldehydes, are reductively converted to the trimethylsilyl ethers of the corresponding alcohols in high yields by treatment with this reagent system in dichloromethane or ...