A practical method for activation of commercial lithium hydride: reductive silylation of carbonyl compounds with lithium hydride and chlorotrimethylsilane

T Ohkuma, S Hashiguchi, R Noyori

文献索引：Ohkuma, Takeshi; Hashiguchi, Shohei; Noyori, Ryoji Journal of Organic Chemistry, 1994 , vol. 59, # 1 p. 217 - 221

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被引用次数: 35

摘要

Commercially available lithium hydride, an essentially inert metal hydride, can be activated as a hydride source by an equimolar amount of chlorotrimethylsilane and a catalytic amount of a Zn salt or Zn powder. Aromatic and aliphatic ketones, as well as nonenolizable aldehydes, are reductively converted to the trimethylsilyl ethers of the corresponding alcohols in high yields by treatment with this reagent system in dichloromethane or ...