Nine of the top 10 drugs contain a chiral active ingredient, and for six of them this ingredient is a single enantiomer small molecule. 1 The demand of enantiopure chiral intermediates as well as finished products for pharmaceutical applications is growing rapidly. A typical target value for the enantiomeric purity is 99.5%. 2 High values of enantio- and diastereoselectivity can be reached by biocatalytic processes. 3 Furthermore, rapid screening and optimisation of ...
