Tetrahedron: Asymmetry

A new enzymatic approach to (R)-Tamsulosin hydrochloride

D Acetti, E Brenna, C Fuganti

文献索引：Acetti, Daniela; Brenna, Elisabetta; Fuganti, Claudio Tetrahedron Asymmetry, 2007 , vol. 18, # 4 p. 488 - 492

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被引用次数: 17

摘要

Nine of the top 10 drugs contain a chiral active ingredient, and for six of them this ingredient is a single enantiomer small molecule. 1 The demand of enantiopure chiral intermediates as well as finished products for pharmaceutical applications is growing rapidly. A typical target value for the enantiomeric purity is 99.5%. 2 High values of enantio- and diastereoselectivity can be reached by biocatalytic processes. 3 Furthermore, rapid screening and optimisation of ...