Organic letters

Biaryl Synthesis via Decarboxylative Pd-Catalyzed Reactions of Arenecarboxylic Acids and Diaryliodonium Triflates

JM Becht, CL Drian

Index: Becht, Jean-Michel; Le Drian, Claude Organic Letters, 2008 , vol. 10, # 14 p. 3161 - 3164

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Citation Number: 125

Abstract

A novel simple and efficient synthesis of biaryls via a Pd-catalyzed decarboxylative cross- coupling reaction of arenecarboxylic acids and diaryliodonium triflates is described. The PdCl2/DPEphos catalytic system in the presence of Ag2CO3 in DMSO was found to be the most efficient. Various biaryls, including sterically hindered biaryls, were synthesized with yields ranging from 37 to 85%.